About Us > Faculty & Staff > Faculty > Magnus Bergkvist

Assistant Professor of Nanobioscience

Degrees:

• Ph.D., Surface Biotechnology, Uppsala University, Uppsala, Sweden (2002)
• B.Sc., Chemical Engineering, Mälardalen University, Eskilstuna, Sweden (1995)

Areas of research:

• Nanobiotechnology
• Bionanofabrication
• Biological structures
• Nanoparticle synthesis
• Surface chemistry
• Surface characterization
• Atomic Force Microscopy

Description of Research:

Dr. Bergkvist's research interests involve several areas within nanobioscience and nanoengineering.

Bionanofabrication/Biomimetics
Nature has over millions of years developed nanostructured systems and functional materials with unique properties, many capable of organized self-assembly in a bottom-up fashion. From a nanoengineering stand point it is advantageous to either utilize these biological systems as is, use components from them or to mimic their function to create new nanostructured materials with advanced function. Dr Bergkvist's research is aimed at creating engineered nanostructures and multi-functional materials by taking advantage of naturally occurring biological nanostructures, such a two dimensional self-assembled protein crystals, viral components and peptides. This "bionanofabrication" approach open alternative routes to create advanced materials with potential use in several diverse fields such as life-science (sensing, targeting and treatment applications), and energy (catalysts, harvesting and storage) etc. His expertise in surface science, colloidal chemistry, nanoparticle synthesis and biochemistry allows him to develop novel bionanofabrication techniques using a range of materials and biological templates.

Nanobiotechnology at interfaces
Most biotechnological applications involve various non-biological interfaces, whether they are metallic, ceramic, polymeric or composite materials. Dr Bergkvist is on a fundamental, as well as a practical level interested how biological materials interact with these "non-biological" interfaces and how to manipulate and control that interaction. This area of research include biomolecular and organic molecular self-assembly, protein structure/function on surfaces, biophysics, cell-cell and cell-surface interactions. Materials of interest include for example, soft/hard polymeric materials for tissue engineering and emerging materials for semiconductor and VLSI fabrication which can be incorporated in electronic biosensor/diagnostic applications.

As an natural extension to effectively control biological interfacing to material, Dr. Bergkvist's is also engaged in research regarding surface characterization and surface chemical modification of interfaces (Self-assembled monolayer chemistry, etc.). Current focus in this area is on the modification of polymeric materials and high-K dielectrics.

Nanofabrication
Current nanobioscience research takes advantage of advanced nanofabrication technology integrated with biology for several purposes. We are interested in the fabrication of nanodevices as a mean to study biological processes (neuron signaling, single cell behavior, biophysics and biological assembly etc.), but also as for developing integrated bio-nano devices where biology and nanotechnology working in unison (applications involving MEMS, diagnostics, tissue engineering etc). CNSE offers unique, world class VLSI fabrication facilities where biological nanotechnology applications can be developed and scaled up to production levels needed to take developments in the laboratory to the masses. Above mentioned research come into play where control/tuning of surface chemistry and interfacial properties, combined with nanofabrication techniques enable layer-by-layer assembly, allow bottom-up self-assembled multilayer chemistries and provide guided patterning of biological molecules for fundamental research or practical integration in functional nanodevices.

Nanoparticle/Nanowire synthesis
A key component in many nanosystems today involve organic/inorganic nanoparticles and nanowires. Dr. Bergkvists's lab is involved with the synthesis and derivatization of metal, magnetic, semiconductor and organic nanoparticles/vesciels for multiple applications in material and life-science.

Publications:

Xiaobin Xu, Vibhu Jindal, Fatemeh Shahedipour-Sandvik, Magnus Bergkvist, Nathaniel C. Cady.
"Immobilization and Hybridization of DNA on Group III Nitride Semiconductors"
Accepted for publication in Applied Surface Science (2009)

Villa, C. H.; McDevitt, M. R.; Escorcia, F. E.; Rey, D. A.; Bergkvist, M.; Batt, C. A.; Scheinberg, D. A., "Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor-Targetable Carbon Nanotubes". Nano Letters. 2008, 8, (12), 4221-4228.

http://dx.doi.org/10.1021/nl801878d

Nelson C.D.S, Minkkinen E, Bergkvist M, Hoelzer K, Fisher M, Bothner B and Parrish C. "Detecting small changes and additional peptides in the canine parvovirus capsid structure". J. Virol. 2008, http://jvi.asm.org/cgi/reprint/JVI.00972-08v1

Bergkvist, M., N. Niamsiri, et al.. Substrate Selective Patterning on Lithography Defined Gold on Silica: Effect of end-group functionality on intermolecular layer formation. Surface Science (2008), 602 (12). 2121-2127 http://dx.doi.org/10.1016/j.susc.2008.04.027

Barrett J. Nehilla, Magnus Bergkvist, Ketul C. Popat and Tejal A. Desai
Purified and Surfactant-free Coenzyme Q10-loaded Biodegradable Nanoparticles
International Journal of Pharmaceutics (2008), 348 (1-2), 107-114
http://dx.doi.org/10.1016/j.ijpharm.2007.07.001

Nuttawee Niamsiri, Magnus Bergkvist, Soazig Delamarre et. al.
Insight in the role of bovine serum albumin for promoting the in situ surface growth of polyhydroxybutyrate (PHB) on patterned surfaces via enzymatic surface-initiated polymerization. Colloids and Surfaces B: Biointerfaces (2007), 60 (1), 68-79

http://dx.doi.org/10.1016/j.colsurfb.2007.05.023

Sonny S Mark, Magnus Bergkvist, Parijat Bhatnagar, et.al
Thin Film Processing Using S-layer Proteins: Biotemplated Assembly of Colloidal Gold Etch Masks for Fabrication of Silicon Nanopillar Arrays. Colloids and Surfaces B: Biointerfaces 2007, Vol 57, Issue 2, 161-173.
http://dx.doi.org/10.1016/j.colsurfb.2007.01.015

Mark. S.S, Bergkvist. M, Yang. X, et.al
Self-Assembly of Dendrimer-Encapsulated Nanoparticle Arrays Using 2-D Microbial S-Layer Protein Biotemplates. Biomacromolecules 2006, 7, 1884-1897

Mark. S.S, Bergkvist. M, Yang. X, et.al.
Bionanofabrication of Metallic and Semiconductor Nanoparticle Arrays Using S-Layer Protein Lattices with Different Lateral Spacings and Geometries, Langmuir, 2006 (22), p. 3763-3774

Bergkvist. M, Mark. S.S, Yang. X, Angert E.R, Batt. C.A.
Bionanofabrication of Ordered Nanoparticle Arrays: Effect of Particle Properties and Adsorption Conditions, Journal of Physical Chemistry B, 2004. 108(24): p. 8241-8248.

Bergkvist M, Carlsson J, Oscarsson S. 2003. Surface dependant conformations of human plasma fibronectin adsorbed to silica, mica and hydrophobic surfaces, studied with Atomic Force Microscopy. Journal of Biomedical Materials Research 64A(2):349-356

Bergkvist. M, Oscarsson. S
Atomic Force Microscopy studies of the conformation of human plasma fibronectin adsorbed to silica, mica and hydrophobic surfaces.
A. Ravaglioli and A. Krajewski, editors Ceramics, Cells and Tissues: Biomimetic Engineering, Ravenna: Tipografia Moderna 2001, vol 7.

Ledung G, Bergkvist M, Quist AP, Gelius U, Carlsson J, Oscarsson S. 2001. Novel method for preparation of disulfides on silicon. Langmuir 17(20):6056-6058

Bergkvist M, Carlsson J, Oscarsson S. 2001. A method for studying protein orientation with atomic force microscopy using relative protein volumes. Journal of Physical Chemistry B 105(10):2062-2069.

Carlsson L, Påhlson C, Bergkvist M, Ronquist G, Stridsberg M. 2000. Antibacterial activity of human prostasomes. The Prostate 44:279-286.

Herbig J, Reimann CT, Bergqvist M, Oscarsson S, Vorobyova IV. 1999. Surface track formation on mica surfaces due to grazing incidence 20.2 MeV C-60 ions: a comparative study employing shadow-replica electron microscopy, tapping-mode and phase- imaging scanning force microscopy. Nuclear Instruments & Methods in Physics Research Section B- Beam Interactions with Materials and Atoms 149(1-2):119-128.

Bergkvist M, Carlsson J, Karlsson T, Oscarsson S. 1998. TM-AFM Threshold Analysis of Macromolecular Orientation: A Study of the Orientation of IgG and IgE on Mica Surfaces. Journal of Colloid and Interface Science 206:475-481.

Gogoll A, Gomes J, Bergkvist M, Grennberg H. 1995. Configurational Assignment of Acyclic (-Allyl)Palladium Complexes. An Analytical Application of Chelating Nitrogen Ligands. Organometallics 14:1354.

Book Chapters:

Integration of Microfabrication and Surface Functionalization Strategies for Analysis of Cell-Surface Interactions in "Biomaterial and Biomedical Engineering". Niamsiri, N., Bergkvist, M. and Batt, C. A. (2007) Editors: Öchsner, A. , Ahmed, W., and Ali, N., Trans Tech Publications, Switzerland.

Methods for studying orientation of surface adsorbed proteins. in "Encyclopedia of Colloid and Interface Science". Bergkvist, M. (2002), Marcel Dekker Inc. Editor: Arthur Hubbard